首页> 外文OA文献 >A Detailed Urinary Excretion Time Course Study of Captan and Folpet Biomarkers in Workers for the Estimation of Dose, Main Route-of-Entry and Most Appropriate Sampling and Analysis Strategies
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A Detailed Urinary Excretion Time Course Study of Captan and Folpet Biomarkers in Workers for the Estimation of Dose, Main Route-of-Entry and Most Appropriate Sampling and Analysis Strategies

机译:工人中Captan和Folpet生物标志物的详细尿排泄时间过程研究,以估算剂量,主要进入途径和最合适的采样和分析策略

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摘要

Captan and folpet are two fungicides largely used in agriculture, but biomonitoring data are mostly limited to measurements of captan metabolite concentrations in spot urine samples of workers, which complicate interpretation of results in terms of internal dose estimation, daily variations according to tasks performed, and most plausible routes of exposure. This study aimed at performing repeated biological measurements of exposure to captan and folpet in field workers (i) to better assess internal dose along with main routes-of-entry according to tasks and (ii) to establish most appropriate sampling and analysis strategies. The detailed urinary excretion time courses of specific and non-specific biomarkers of exposure to captan and folpet were established in tree farmers (n = 2) and grape growers (n = 3) over a typical workweek (seven consecutive days), including spraying and harvest activities. The impact of the expression of urinary measurements [excretion rate values adjusted or not for creatinine or cumulative amounts over given time periods (8, 12, and 24 h)] was evaluated. Absorbed doses and main routes-of-entry were then estimated from the 24-h cumulative urinary amounts through the use of a kinetic model. The time courses showed that exposure levels were higher during spraying than harvest activities. Model simulations also suggest a limited absorption in the studied workers and an exposure mostly through the dermal route. It further pointed out the advantage of expressing biomarker values in terms of body weight-adjusted amounts in repeated 24-h urine collections as compared to concentrations or excretion rates in spot samples, without the necessity for creatinine corrections
机译:Captan和Folpet是农业上广泛使用的两种杀真菌剂,但是生物监测数据主要限于测量工人现场尿液样本中的Captan代谢物浓度,这使得内部剂量估算,根据执行任务的每日变化以及结果的解释变得复杂。最合理的接触途径。这项研究旨在对野外工作人员对captan和folpet的暴露进行重复的生物学测量(i)以根据任务更好地评估内部剂量以及主要进入途径,以及(ii)建立最合适的采样和分析策略。在典型的工作周(连续七个工作日)中,在树木种植者(n = 2)和葡萄种植者(n = 3)中确定了暴露于硫丹和棉ol的特异性和非特异性生物标志物的详细尿排泄时间过程。收获活动。评估尿液测量值的表达[在给定时间段(8、12和24小时)内针对肌酐或累积量调整或未调整的排泄率值]。然后通过使用动力学模型,根据24小时累积尿量估算吸收剂量和主要进入途径。时间进程表明,喷洒过程中的暴露水平高于收获活动。模型模拟还表明,在研究的工人中吸收有限,并且主要通过皮肤途径暴露。它进一步指出了在重复24小时尿液收集中以体重调整量表达生物标志物值的优势,与现场样本中的浓度或排泄率相比,无需肌酐校正。

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